Higuchi connors phase solubility techniques.

[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.The solubilities of voriconazole, ketoconazole, and clotrimazole with and without hydroxybutenyl-β-cyclodextrin (HBenBCD) in aqueous media were examined. The solubility of these antifungal drugs was significantly improved by complexation with HBenBCD. Both the pH and the type of buffer used to adjust the medium pH had a very significant effect on drug solubilities and the apparent binding ...

where [D/CD] is the concentration of dissolved drug-cyclodextrin complex, [CD] is the concentration of dissolved free cyclodextrin and slope is the slope of the phase solubility profile (Higuchi, Connors, 1965 Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and Instrumentation.Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …The solubility diagram is useful for explaining inclusion complexation of poorly soluble compounds with cyclodextrins as a host in water because it gives not only the solubilizing ability of host but also the stability constant of the complexes by analyzing the solubility curves (Higuchi & Connors, 1965).Fig. 2 shows the phase solubility …

Jan 1, 2011 · In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.

Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase …2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels …Determination of stoichiometry of host and guest by phase solubility method. The stoichiometry of host and guest was established by phase solubility technique described by Higuchi-Connors [24, 25]. Briefly, an excess weighed amount of EFV was added to series of HP-β-CD solutions (3–15 mM).After equilibrium was attained, the suspensions were filtered through 0.45 µm cellulose membrane filter, the filtrates diluted with the mobile phase and analyzed by HPLC. The apparent complexation constants for drug/cyclodextrin complexes (K 1:1) were determined according to the phase-solubility method of Higuchi and Connors.PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.

The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …

Article Original Paper Published: 08 August 2022 Mangiferin/ β -cyclodextrin complex: determination of the Inclusion constant in aqueous solution by Higuchi-Connors method and molecular absorption and photoluminescence UV spectroscopies at pH 3.4 Lucero Hernández-García, Alberto Rojas-Hernández & Annia Galano

The effect of L-arginine was investigated on complexation efficiency of β-cyclodextrin towards Epalrestat in an aqueous media through phase solubility according to Higuchi and Connors. Phase ...method described by Higuchi and Connors (1965). Excess amounts of NB (5 mg) were ... Phase-solubility techniques. Adv Anal Chem Instrum 4: 117–212. Kadri M ...Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.Solubility diagrams exhibit AL type according to the Higuchi and Connors classification [23], showing a linear increase ... Phase-solubility techniques. Adv Anal ...

Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...The Higuchi–Connors phase-solubility method8) is very often used to determine K 1:1, as a part of a formulation study. This method is based on the effect of a complex forming lig-and, e.g. CD, on the solubility of the drug. The intrinsic solu-bility (S 0) and the slope of the phase-solubility diagram are then used to calculate K 1:1Phase solubility studies. Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α ...Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem Instrum, 1965, 4, 117-210. has been cited by the following article: Article. Solid Dispersion Incorporated Microcapsules: Predictive Tools for Improve the Half Life and Dissolution Rate of Pioglitazone Hydrochloride.where [D/CD] is the concentration of dissolved drug-cyclodextrin complex, [CD] is the concentration of dissolved free cyclodextrin and slope is the slope of the phase solubility profile (Higuchi, Connors, 1965 Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and Instrumentation.Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review.PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.

Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.Moreover, phase-solubility analysis shows that propyl-paraben and ethylparaben, at room temperature, can also form solid solutions whose solubility is related to the composition of the solid phase at equilibrium. ... T. Higuchi, A. Connors. Phase-solubility Techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus …also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965). Assuming that the stoichiometry of the inclusion complex is 1:1, the solubility constant is given by the following equation: (1) K 1: 1 = s l o p e [T ...The aqueous solubility of 1 linearly increased as a function of HP-β -CD concentration and showed features of an A -CD concentration and showed features of an AL type diagram. Thermodynamic parameters were obtained by using the temperature dependence of the stability constant at temperatures of between 25 and 37 type diagram.The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending.

May 1, 2022 · All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ...

also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...

Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0-4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ...The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).Abstract. Solubility is one of the most important physicochemical properties studied during pharmaceutical preformulation. For liquid dosage form development, accurate solubility …Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...In both cases, concentrations between 0.2% to 20% w/v of CDs in water were used, and the phase solubility studies were carried out according to the method reported by Higuchi and Connors . An excess amount of the berberine chloride was added to the aqueous solutions containing increasing concentrations of RMβCD (1.52 to 152.67 mM) or HPβCD (1 ...Phase solubility stud ies were performed according to the method . reported by H iguchi and Connors [14]. Ex cess drug ... Higuchi T, Connors K. Phase-solubility techniques. Adv AnalThe shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...In a famous publication by Higuchi and Connors, complexes were classified based on the phase solubility profiles derived from the molecular interactions between the host and the guest...Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …

The apparent stability constant of the KET- BCD complex, assuming 1:1 stoichiometry, were calculated from the slope of the initial straight portion of the phase solubility diagrams as KH = slope/S0(1 - slope) where So is the solubility of the pure drug (Higuchi and Connors, 1965). All the data are the average of three determinations. 2.3.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone ...Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α-CD and taken in …Instagram:https://instagram. substance abuse treatment program policies and proceduresbraun basketballcreating an action planku vs k state In the phase-solubility diagram, the slope was lower than the unit, and the inclusion ratio of BA–β-CD was 1:1. The apparent stability constant (K 1:1) obtained from the Higuchi–Connors formula was 1.3094 × 10 3 mol −1, which showed the existence of favourable interactions. A larger K 1:1 value corresponded to a higher BA solubility ... como hablan los espanolesaustin rewves The solubility of CUR increased linearly with increasing concentrations of β-CD, represented as an A L type phase solubility curve (Higuchi & Connors, 1965; Jiang et al., 2019). The results of ANONA of the phase solubility model were provided in Table 1. F value (409.54) was extremely significant (p value < 0.001) suggesting that the model was ... nick bahe wikipedia Phase solubility of GO/β-CD complex. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). Excess amounts of GO were added to 10 ml of water solution of β-CD at different concentrations ranging from 0 to 9.5 mM.Phase solubility studies. Phase solubility studies were carried out as described by Higuchi & Connors (Higuchi & Connors, 1965). Excess amount of caffeic acid was added to vials containing both CD and ethanol. The concentration of CD varied from 0 to 10 mM and the percentage of ethanol from 0 to 45% v/v.In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.