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Modafinil is a non-amphetamine central nervous system (CNS) stimulant with wakefulness-promoting properties. It is used in the treatment of conditions which cause excessive daytime sleepiness. In the United States, modafinil is FDA-approved for the treatment of the following in adults: narcolepsy, sleep work shift disorder, and obstructive sleep apnea (adjunct to continuous positive airway ...INTRODUCTION. Modafinil (2-[(diphenylmethyl) sulfinyl] acetamide) is an exclusive psychostimulant with a waking effect, and is a special medicine that can only be prescribed to shift workers and patients suffering from narcolepsy or sleep apnea (Figure 1)[1,2].Modafinil has been commercialized as a waking drug in 2003 [].The normal half …Modafinil is believed to increase dopamine levels, which helps improve wakefulness. It also stimulates mood, thinking, and feelings. Similarly, Adderall improves attention and focus while decreasing impulsivity and aggression, bringing the brain to …Most research on modafinil’s wake-promoting mechanism has focused on monoaminergic effects showing modafinil stimulates histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems in the brain, but researchers have not been able to isolate a single site of action or locate major receptor binding.

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Modafinil is the active ingredient in Provigil. It’s also the generic version of Provigil. Sunosi and modafinil can cause similar side effects, including headache, nausea, and anxiety .

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