Higuchi connors phase solubility techniques.

In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations.Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...

Sep 1, 2010 · HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 ... ResearchGate | Find and share research

Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α-CD and taken in …

For this purpose, the phase solubility of curcumin was assessed using Higuchi and Connors. ... Phase-solubility techniques. Advances in. Analytical Chemistry and Instrumentation, 4 (2), 117–212.The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ...Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...Jan 1, 2011 · In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation. Phase solubility studies. Increasing concentrations (0-10 mM) of CD solutions were added to a series of stoppered glass tubes containing an excess amount of PD at 25°C, according to the method reported by Higuchi and Connors (1965).

May 1, 2022 · All experiments were repeated three times. According to the linear part of the phase solubility curve, the stability constant (Kc) was calculated using the Higuchi-Connors equation. (1) K c = S l o p e S 0 × (1-S l o p e) S 0: the solubility of NAR without β-CD. The solubilizing efficiency of β-CD was evaluated by the complexation efficiency ...

Shake flask method was employed for the aqueous solubility measurements, performed in triplicates by Higuchi and Connors method . An excess amount of cocrystals were added to the flask containing distilled water. The solutions were vortexed for 2 min and placed on a rotary shaker at 100 rpm and 27±0.5° for 24 h. ... Higuchi TK, Connors A. …

Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase solubility diagram ...The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl) …Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...The shake-fl ask method proposed by Higuchi and Connors is the most reliable and widely used solubility measurement method. ... K. A. Connors, Phase-solubility techniques, Adv. Anal. Chem. Instr ...In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant …The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug solubility ...

complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. AnThe Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, …Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently …The results showed an increase in the apparent solubility of ibuprofen in the presence of maltodextrins that depended on their ionization state. The freeze-drying method was used to prepare solid complexes, while physical mixtures were obtained by simple blending. All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...Using the approach of Higuchi and Connors, phase-solubility studies were performed at increasing concentrations of the three CD. Fig. 2 shows that the solubility of CBD increased linearly with the concentrations of HPβCD and HPγCD which corresponds to the AL type profile (formation of 1:1 inclusion complexes). On the contrary, the phase ...

1 Ara 2009 ... Solubility Studies—Phase Solubility Experiments. Equilibration Time ... Higuchi T, Connors K. Phase-solubility techniques. Adv Αnal. Chem ...

Jan 1, 2011 · In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation. T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. …The objective of this study was to learn whether or not the pattern recognition methods, such as agglomerative cluster analysis (CA) and principal component analysis (PCA), can be used as supplementary techniques for identification of salicylamide (SAA) inclusion complexes with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP …Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique. Research J. Pharm. and Tech. 2020; 13(10):4557-4564. doi: 10.5958/0974-360X.2020.00803.3 Cite(Electronic): Gaurav Bhaduka, Jitendra Singh Rajawat. Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique.Phase solubility. Compatibility of host and guest relationship was determined by Higuchi-Connors phase solubility method [16]. Excess amount of drug was added in flask containing different molar ratios of βCD mixed in distilled water. Flasks were placed in water bath (TSSWB15-USA) at 37 ± 2 °C with speed of 100 rpm for 72 h.A 1:1 stoichiometry was proposed by the phase solubility studies both in presence and absence of PVP. The most plausibe mode of inclusion of arteether into the CD cavity is revealed by molecular modeling studies utalizing Fast Rigid Exhaustive Docking acronym.Phase Solubility Studies. Phase solubility studies were carried out at room temperature (21 ± 1°C) following the method of Higuchi and Connors . Excess amounts of OME were weighed in glass flasks to which 10 ml of boric/borate buffer pH = 10 were added. These flasks contained increasing amounts of βCD (0–1.5%, w/v) or MβCD (0–5%, w/v).Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarOne of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review.

complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. An

Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 2018 ; Higuchi & Connors 1965 ). Briefly, an excess of KME was added to 200 μL aqueous solutions of different HP-β-CD concentrations (1, 2, 4, 6, 8, and 10 mM).

7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ...The influence of HPB-CD on the solubility of BSC II compounds using phase solubility method (Higuchi ... Phase-solubility profiles of carbamazepine, danazol and ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarPHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. Phase solubility study. Phase-solubility study is a traditional and useful approach not only to determine the value of the stability constant, but also to give insight into the stoichiometry of the equilibrium. The practical and phenomenological implications of phase solubility study were developed by Higuchi and Connons (Higuchi & Connors ...The solubility profile of complexes of rofecoxib prepared using HPβ-CD as the complexing agent in a molar ratio of 1∶1 by the spray-drying method in pH 1.2 and pH 7.4 indicated that the acid solubility of rofecoxib was enhanced considerably by formation of an inclusion complex with HPβ-CD.Phase-solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors [13]. An excess amount of CAR was added to the aqueous solutions of Soluplus® in water containing increasing concentrations of Soluplus® (0–20% w/v).Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following …To establish the increase of ezetimibe water solubility, caused by the influence of rising concentration of cyclodextrins in the aqueous solution, UV-VIS spectrophotometry measurements were performed . Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug ...In the present study, the solubility of aniracetam alone was 4.53 mg/mL. This is a significant increase from 0.109 mg/mL, which is reported in the literature . The marked increase in apparent solubility may be explained by the limited samples used within the phase solubility analysis at lower HP-β-CD concentrations.PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir.

HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 ...Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117-212. [Google Scholar] 26. Doile KM ...Instagram:https://instagram. morgan duncanku 2023 2024 calendarphd in theatrefootball rodriguez Phase solubility studies for Cur/Na 2 GA systems were carried out in aqueous systems at different temperatures to calculate the ... (A L-type relationships), suggesting the formation of 1:1 ‘molecular relations’ of associated complexes/micelles (Higuchi & Connors, Citation 1965). Thus, ... Connors KA. (1965). Phase-solubility techniques. In: Reilley CN, ed. …T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following … texas game longhornssanstone rock All the phase solubility diagrams displayed a typical AL type diagram (i.e. linear increases in luteolin solubility with increasing CD concentrations) within the concentration range studied, indicating a 1:1 stoichiometry of the complexes between luteolin and the five different CDs studied (Higuchi & Connors, 1965). This means that each …Phase solubility studies. Degree of complexation between nanosponges and SMX has been studied by phase solubility studies as described by Higuchi and Connors . Briefly, an excess amount of SMX (10 mg/ml), and predetermined concentrations of nanosponges in the range of 0–4% (w/v) were added in volumetric flasks in a PBS medium, and placed on a ... wichita state baseball field Phase Solubility Studies. Phase solubility studies were carried out based on the methods described by Higuchi and Connors . Excess amount of POS (30 mg) was added to aqueous solutions of β-CD and DM-β-CD with various concentrations (0 to 15.00 mM for β-CD and 0 to 35.00 mM for DM-β-CD).Phase solubility studies of BDQ in the presence of SBE-β-CD was performed according to the method described by Higuchi and Connors [30] and previously ...